图片来源于：CDC/ Robert Denty
2020年2月28日，在瑞士日内瓦举行的“世卫组织关于2020-2021年北半球流感季节使用的流感病毒疫苗组成的咨询信息会议”公布了2020-2021年北半球流感季节使用的流感病毒疫苗的推荐毒株信息：
表1：2020-2021年北半球流感季节使用的流感病毒疫苗推荐毒株
|
2020-2021年北半球流感季节使用的流感病毒疫苗推荐毒株 |
||
| 来源 |
鸡胚 |
细胞 |
| 三价
疫苗 |
A/Guangdong-Maonan/SWL1536/2019(H1N1)pdm09-like virus | A/Hawaii/70/2019 (H1N1)pdm09-like virus |
| A/Hong Kong/2671/2019 (H3N2)-like virus | A/Hong Kong/45/2019 (H3N2)-like virus | |
| B/Washington/02/2019 (B/Victoria lineage)-like virus | B/Washington/02/2019 (B/Victoria lineage)-like virus | |
| 四价
疫苗 |
A/Guangdong-Maonan/SWL1536/2019 (H1N1)pdm09-like virus | A/Hawaii/70/2019 (H1N1)pdm09-like virus |
| A/Hong Kong/2671/2019 (H3N2)-like virus | A/Hong Kong/45/2019 (H3N2)-like virus | |
| B/Washington/02/2019 (B/Victoria lineage)-like virus | B/Washington/02/2019 (B/Victoria lineage)-like virus | |
| B/Phuket/3073/2013 (B/Yamagata lineage)-like virus. | B/Phuket/3073/2013 (B/Yamagata lineage)-like virus | |
鸡胚：A/Guangdong-Maonan/SWL1536/2019(H1N1) pdm09-like virus
细胞：A/Hawaii/70/2019 (H1N1)pdm09-like virus
2. 推荐的H3N2 毒株的区别：
鸡胚：A/Hong Kong/2671/2019 (H3N2)-like virus
细胞：A/Hong Kong/45/2019 (H3N2)-like virus
图片来源于：www.who.int/influenza/vaccines/virus/recommendations/2020-21_north/en/
不仅如此，在与去年相比较，流感疫苗的抗原组分发生了较大改变：
三价疫苗的抗原成分全部发生改变，四价疫苗只有B/Phuket/3073/2013 (B/Yamagata lineage)-like virus 未有变化；
流感病毒A 型和流感病毒B 型的抗原成分发生了巨大的改变，从2018-2019、2019-2020、2020-2021 年推荐毒株来看，流感病毒毒株的抗原成分的更新也越来越快，流感病毒B 型的毒株也开始改变并流行起来，且随着疫苗毒株完全不同及年年更新，同时要着重注意流感病毒B 型带来的流行不能忽视。WHO推荐流感疫苗毒株具体差异如下：
1. H1N1 毒株的区别：
2018-2019：A/Michigan/45/2015 (H1N1) pdm09-like virus
2019-2020：A/Brisbane/02/2018 (H1N1)pdm09-like virus
2020-2021：A/Hawaii/70/2019 (H1N1)pdm09-like virus
2. H3N2 毒株的区别：
2018-2019：A/Singapore/INFIMH-16–0019/2016 (H3N2)-like virus
2019-2020：A/Kansas/14/2017 (H3N2)-like virus
2020-2021：A/Hong Kong/45/2019 (H3N2)-like virus
3. B/Victoria 毒株的区别：
2018-2019：B/Colorado/06/2017-like virus (B/Victoria lineage)
2019-2020：B/Colorado/06/2017-like virus (B/Victoria/2/87 lineage)
2020-2021：B/Washington/02/2019 (B/Victoria lineage)-like virus
表2：2018-2019、2019-2020、2020-2021年北半球流感季节使用的流感病毒疫苗推荐毒株的比对
|
2018-2019 |
2019-2020 |
2020-2021 |
|
| 三价
疫苗 |
A/Michigan/45/2015 (H1N1) pdm09-like virus | A/Brisbane/02/2018 (H1N1)pdm09-like virus | A/Guangdong/Maonan/SWL1536/2019(H1N1)
pdm09-like virus |
| A/Singapore/INFIMH-16–0019/2016 (H3N2)-like virus | A/Kansas/14/2017 (H3N2)-like virus | A/Hong Kong/2671/2019 (H3N2)-like virus | |
| B/Colorado/06/2017-like virus (B/Victoria lineage) | B/Colorado/06/2017-like virus (B/Victoria/2/87 lineage) | B/Washington/02/2019 (B/Victoria lineage)-like virus | |
| 四价
疫苗 |
A/Michigan/45/2015 (H1N1) pdm09-like virus | A/Brisbane/02/2018 (H1N1)pdm09-like virus | A/Guangdong-Maonan/SWL1536/2019 (H1N1)pdm09-like virus |
| A/Singapore/INFIMH-16–0019/2016 (H3N2)-like virus | A/Kansas/14/2017 (H3N2)-like virus | A/Hong Kong/2671/2019 (H3N2)-like virus | |
| B/Colorado/06/2017-like virus (B/Victoria lineage) | B/Colorado/06/2017-like virus (B/Victoria/2/87 lineage) | B/Washington/02/2019 (B/Victoria lineage)-like virus | |
| B/Phuket/3073/2013-like virus (B/Yamagata lineage) | B/Phuket/3073/2013 (B/Yamagata lineage)-like virus | B/Phuket/3073/2013 (B/Yamagata lineage)-like virus |
内容来源于WHO 及整理
供稿：Harris
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